The Seven Proven Anti-Aging Benefits of NMN
A decline in the body’s capacity to repair DNA and maintain healthy cells is associated with aging and a host of other health issues. This process relies on nicotinamide mononucleotide (NMN). The human body contains NMN naturally.
Enzymes and proteins that aid in DNA and epigenome repair and maintenance, including PARPs and sirtuins, rely on NAD+.
Nicotinamide mononucleotide (NMN) is an anti-aging supernova with numerous benefits to health and longevity. According to scientific research, NMN (especially from reputable longevity supplement brands) has a number of health and longevity benefits.
Increasing Energy Levels
Research on mice has shown an 80% improvement in endurance and stamina. Many report a noticeable increase in energy levels after taking sufficient NMN. Taking NMN for an extended length of time can raise the body’s NAD levels, according to a review of NMRN research up until May 2024. As a result, the mitochondria’s energy metabolism can become more efficient, leading to better energy utilization by the body.
Boosting Metabolism
There is an increased risk of developing multiple diseases as metabolism slows down with age. Results from a human trial demonstrate that NMN increases gene activity and improves insulin sensitivity in muscles. This is because NMN makes insulin more effective at triggering sugar uptake. The potential for NMN to be used as a treatment for aging-related diseases is highlighted by researchers. A higher metabolic rate is a result of both the enhanced energy consumption and the factors discussed in a 2024 review.
Supporting Healthy Insulin Sensitivity
The amount of muscular activity increases at the 10-week mark. Two important findings were drawn from a clinical study that included women who had prediabetes. One was a rise in NMN metabolites in skeletal muscle, a sign of increased NAD+ usage by the muscles. The second finding suggested that NMN might help regulate gene expression related to muscle remodeling—the process of restocking muscle proteins, organelles, and cell populations—and promote healthy insulin sensitivity in skeletal muscle. Every day, trial participants were given an extra 250 mg of NMN.
Promoting Heart Health
A healthy heart relies on a constant supply of energy, which is provided primarily by mitochondria. It is common to discover mitochondrial issues when hearts are not functioning properly. The proper operation of mitochondria depends on NAD+.
A healthy heart can benefit from NMN because it is a precursor to NAD+. This was proven in a study where mice were subjected to stress by having their mitochondrial function impaired. They found that after injecting NMN, the body converted it to NAD+ very quickly. NAD lowers the cell death rate and increases the heart cells’ capacity to work under stress. It also helped lessen scarring, which is a component of cardiac dysfunction.
Improving Brain Function
For the brain to work in harmony, it needs an adequate amount of oxygen and nutrients. The brain uses 20% of the oxygen in the body when at rest, despite accounting for only 2% of total mass. The brain can carry out its functions because blood carries oxygen and nutrients to its active regions.
Because of this, unblocking blood flow to the brain is crucial for achieving balanced brain functioning. Giving NMN to elderly mice enhances brain function, according to the research, by widening brain blood vessels and increasing blood flow to the brain.
Promoting DNA Repair
Age causes a gradual deterioration of DNA codes. Repairing DNA damage can delay or even halt the onset of age-related diseases. Sirtuins are enzymes that support NAD and are responsible for protecting our health span.
Telomere length is an indicator of aging, and sirtuins play a crucial role in DNA repair by stabilizing this length.
Scientists have shown that when mice are given NMN, sirtuins are activated.
Additionally, NMN aids in the restoration of DNA damaged by radiation and the natural aging process.
Enhancing Eye Function
Reduced levels of NAD+ cause fast neurodegeneration in the eye, which ultimately results in blindness. Avoiding side effects and regaining vision are both made possible by increasing NMN levels. Eye function and tear production are both markedly improved with long-term administration of NMN, according to one study. Additionally, another study indicated that NMN triggers DNA maintenance and a health-promoting protein, which in turn protects eye cells and reduces inflammation in dry eye disease.
Conclusion
A decrease in NAD+ has been associated with a number of diseases. The NAD+ precursor NMN can raise the levels of NAD+ in the body, which can help to reverse age-related issues and slow down the aging process.
